FUNGAL LIVER INFECTION IN MARROW TRANSPLANT RECIPIENTS - PREVALENCE AT AUTOPSY, PREDISPOSING FACTORS, AND CLINICAL-FEATURES

To determine the prevalence of fungal liver infection at autopsy in ma rrow transplant recipients, we reviewed autopsy results for the period 1980-1989. Cases were compared to randomly chosen autopsied controls without fungal infection. Fungal liver infection was found in 67 (9%) of 731 patients. Fungal cultures of liver lesions were positive for 34 of 67 patients, most of whom had been culture-positive for the same f ungal species (largely Candida) during life. Multivariate analysis rev ealed that independent predictors of fungal liver infection were deep fungal infection after transplantation (RR, 35), colonization or super ficial infection after transplantation (RR, 13), and severe liver dysf unction caused by veno-occlusive disease of the liver and/or graft-ver sus-host disease (RR, 7). Clinical and laboratory findings during the last month of life revealed no differences between cases and controls, Liver imaging studies performed during the last 15 days of life had a sensitivity of only 18% for detecting fungal liver lesions.