Objectives. The purpose of this in vitro study was to evaluate shear b
ond strengths and microleakage of seven current generation dentin adhe
sive systems. Methods. Standard box-type Class V cavity preparations w
ere made at the cemento-enamel junction on the buccal surfaces of eigh
ty extracted human molars. These preparations were restored using a mi
crofill composite following application of either All-Bond 2 (Bisco),
Clearfil Liner Bond (Kuraray), Gluma 2000 (Miles), Imperva Bond (Shofu
), OptiBond (Kerr), Prisma Universal Bond 3 (Caulk), Scotchbond Multi-
Purpose (3M), or Scotchbond Dual-Cure (3M) (control). Lingual dentin o
f these same teeth was exposed and polished to 600-grit. Adhesives wer
e applied and composite was bonded to the dentin using a gelatin capsu
le technique. Specimens were thermocycled 500 times. Shear bond streng
ths were determined using a universal testing machine, and microleakag
e was evaluated using a standard silver nitrate staining technique. Re
sults. Clearfil Liner Bond and OptiBond, adhesive systems that include
low-viscosity, low-modulus intermediate resins, had the highest shear
bond strengths (13.3 +/- 2.3 MPa and 12.9 +/- 1.5 MPa, respectively).
Along with Prisma Universal Bond 3, they also had the least microleak
age at dentin margins of Class V restorations. Significance. No statis
tically significant correlation between shear bond strength and microl
eakage was observed in this study. Adhesive systems that include a low
-viscosity intermediate resin produced the high bond strengths and low
microleakage. Similarly, two materials with bond strengths in the int
ermediate range had significantly increased microleakage, and one mate
rial with a bond strength in the low end of the spectrum exhibited mic
roleakage that was statistically greater. Thus, despite the lack of st
atistical correlation, there were observable trends.