MATERNAL ENVIRONMENT DEFINES BLOOD-PRESSURE AND ITS RESPONSE TO TROLEANDOMYCIN IN SPONTANEOUSLY HYPERTENSIVE RATS

Relationship between family-3A cytochrome P-450-dependent (troleandomy cin inhibitable) and maternal environmental-dependent systolic blood p ressure (SEP) was investigated in spontaneously hypertensive rats (SHR ). Adult SHR nursed by foster or natural SHR mothers had indistinguish able SEP. Troleandomycin reduced 50% of Wistar-Kyoto (WKY)-SHR strain difference in SEP. SHR having WKY foster mothers had SEP similar to tr oleandomycin-reduced SHR levels, which was unaffected by troleandomyci n The two components of SEP elevation appear identical. Because observ ations of others demonstrated that WKY fostered to SHR show no SEP inc rease, the maternally dependent/troleandomycin-sensitive component of SEP elevation may reflect epistatic interaction between genes determin ing maternal differences and offspring sensitivity, respectively.