ENDOGENOUS GAMMA-INTERFERON ACTIVATES THYMIDINE PHOSPHORYLASE IN COLORECTAL-CANCER TISSUE

Authors
IWAGAKI H HIZUTA A MORI K YOSHINO T KAWAHARA K TANAKA N ORITA K
Citation
H. Iwagaki et al., ENDOGENOUS GAMMA-INTERFERON ACTIVATES THYMIDINE PHOSPHORYLASE IN COLORECTAL-CANCER TISSUE, Research communications in molecular pathology and pharmacology, 87(3), 1995, pp. 345-352
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
87
Issue
3
Year of publication
1995
Pages
345 - 352
Database
ISI
SICI code
1078-0297(1995)87:3<345:EGATPI>2.0.ZU;2-N
Abstract
We measured neopterin (NPT), an indirect marker of gamma (gamma)-inter feron, and the activity of thymidine phosphorylase (dThdPase) in the a dvancing front of colorectal carcinoma and in normal mucosa. Cancer sh owed a higher concentration of NPT than normal mucosa and also showed significantly higher(p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that e ndogenous gamma-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availabi lity of thymidine.