A CASE OF PAROXYSMAL TONIC UPWARD GAZE ASSOCIATED WITH PSYCHOMOTOR RETARDATION

The authors report a female with paroxysmal tonic upward gaze similar to the cases reported by Ouvrier and Billson (1988). She developed abn ormal eye-movements at the age of six months. Several anticonvulsants and levodopa were not effective in the control of the episodes; howeve r, anticonvulsants and levodopa were not effective in the control of t he episodes; however, her upward eye-deviations spontaneously decrease d during the one-year observation. Her clinical features were almost i dentical to those reported by Ouvrier and Billson, except that she had neurodevelopmental disorder and abnormal brain MRI. More data are req uired to clarify this unique phenomenon.