A MORBILLIVIRUS THAT CAUSED FATAL DISEASE IN HORSES AND HUMANS

Authors
MURRAY K SELLECK P HOOPER P HYATT A GOULD A GLEESON L WESTBURY H HILEY L SELVEY L RODWELL B KETTERER P
Citation
K. Murray et al., A MORBILLIVIRUS THAT CAUSED FATAL DISEASE IN HORSES AND HUMANS, Science, 268(5207), 1995, pp. 94-97
Citations number
31
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
268
Issue
5207
Year of publication
1995
Pages
94 - 97
Database
ISI
SICI code
0036-8075(1995)268:5207<94:AMTCFD>2.0.ZU;2-N
Abstract
A morbillivirus has been isolated and added to an increasing list of e merging viral diseases. This virus caused an outbreak of fatal respira tory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 1 0- and 18-nanometer surface projections that gave them a ''double-frin ged'' appearance. The virus induced syncytia that developed in the end othelium of blood vessels, particularly the lungs.