HYPERTROPHIC CARDIOMYOPATHY ASSOCIATED WITH TACROLIMUS IN PEDIATRIC TRANSPLANT PATIENTS

Authors
ATKISON P JOUBERT G BARRON A GRANT D PARADIS K SEIDMAN E WALL W ROSENBERG H HOWARD J WILLIAMS S STILLER C
Citation
P. Atkison et al., HYPERTROPHIC CARDIOMYOPATHY ASSOCIATED WITH TACROLIMUS IN PEDIATRIC TRANSPLANT PATIENTS, Lancet, 345(8954), 1995, pp. 894-896
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
Lancet → ACNP
ISSN journal
01406736
Volume
345
Issue
8954
Year of publication
1995
Pages
894 - 896
Database
ISI
SICI code
0140-6736(1995)345:8954<894:HCAWTI>2.0.ZU;2-A
Abstract
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatri c transplant recipients (3 small bowel with or without liver and 2 liv er) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed o r improved with a lower dose of tacrolimus or after stopping the drug.