HERPES-SIMPLEX VIRUS INDUCES FOS EXPRESSION IN RAT BRAIN-STEM NEURONS

Authors
GIEROBA ZJ ZHU BS BLESSING WW WESSELINGH SL
Citation
Zj. Gieroba et al., HERPES-SIMPLEX VIRUS INDUCES FOS EXPRESSION IN RAT BRAIN-STEM NEURONS, Brain research, 675(1-2), 1995, pp. 329-332
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
675
Issue
1-2
Year of publication
1995
Pages
329 - 332
Database
ISI
SICI code
0006-8993(1995)675:1-2<329:HVIFEI>2.0.ZU;2-6
Abstract
After the injection of Herpes Simplex Virus type 1 into the rat cervic al vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nucl ei were present in the same regions of the brain. A double-labelling p rocedure revealed that most of the virus-positive neurons also contain ed Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is a ssociated with Fos expression in neurons and glial cells.