BICUCULLINE BLOCKS NEUROPEPTIDE Y-INDUCED PHASE ADVANCES WHEN MICROINJECTED IN THE SUPRACHIASMATIC NUCLEUS OF SYRIAN-HAMSTERS

Authors
HUHMAN KL BABAGBEMI TO ALBERS HE
Citation
Kl. Huhman et al., BICUCULLINE BLOCKS NEUROPEPTIDE Y-INDUCED PHASE ADVANCES WHEN MICROINJECTED IN THE SUPRACHIASMATIC NUCLEUS OF SYRIAN-HAMSTERS, Brain research, 675(1-2), 1995, pp. 333-336
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
675
Issue
1-2
Year of publication
1995
Pages
333 - 336
Database
ISI
SICI code
0006-8993(1995)675:1-2<333:BBNYPA>2.0.ZU;2-Q
Abstract
Microinjection of neuropeptide Y (NPY) into the suprachiasmatic nucleu s of the hypothalamus (SCN) during the middle of the subjective day (i .e. circadian time 6) causes large phase advances in circadian rhythms . The present study demonstrates that microinjection of the gamma-amin obutyric acid (GABA) antagonist, bicuculline, completely blocks NPY-in duced phase advances. These data indicate that GABA(A) activity within the SCN may mediate the phase shifting effects of some stimuli on the circadian pacemaker.