Progressive supranuclear palsy (PSP) is characterized by supranuclear
ophthalmoplegia mainly affecting vertical gaze, nuchal dystonia in ext
ension, pseudobulbar palsy, and mental changes. The literature on PSP
has been neurologically oriented whereas the psychiatric aspects have
been relatively neglected. A review of the literature shows that psych
iatric disturbance in PSP is common but with no characteristic pattern
. Cognitive impairment, nonspecific affective and behavioral disturban
ces are commonly found, whereas frank psychosis or bipolar disorder ar
e rare. Misdiagnoses with psychiatric disorders are common and a heigh
tened awareness of the condition is necessary for early diagnosis.