ORGANOTIN(IV) COMPLEXES WITH TETRAETHYL ETHYLENE-DIPHOSPHONATE AND PROPYLENE-DIPHOSPHONATE

The series of organotin halide complexes with tetraethyl ethylene- and propylene-diphosphonates R(n)SnX(4-n) . L [n=0, X=Cl; n=1, R=Me, X=Cl , Br; n=1, R=Ph, X=Cl; n=2, R=Me, Et, Bu, X=Cl, Br; n=2, R=Ph, X=Cl; L =(EtO)(2)P(O)CH(2)CHR'P(O)(OEt)(2), R'=H, Me] were synthesized and cha racterized by means of NMR and Mossbauer spectroscopy. The crystal str ucture of the complex of diphenyltin dichloride with propylenediphosph onate was determined. The complex consists of polymer chains with brid ging bidentate ligands and an octahedral tin environment containing tw o types of phosphoryl fragments. All of the R(2)SnX(2) adducts have tr ans-R(2)SnX(4) geometries of tin coordination octahedra according to t he quadrupole splitting values in the Mossbauer spectra. The P-31 and Sn-119 NMR studies at low temperatures revealed that RSnHal(3), comple xes in solution form isomers with different mutual orientations of pho sphoryl ligands and organic groups in the coordination sphere. The die thyltin dichloride adduct with ethylene-diphosphonate appeared to be a ctive against lung cancer NCI-H522 cells.