CDNA CLONING OF A NCFI-B NUR77-RELATED TRANSCRIPTION FACTOR FROM AN APOPTOTIC HUMAN T-CELL LINE/

Authors
OKABE T TAKAYANAGI R IMASAKI K HAJI M NAWATA H WATANABE T
Citation
T. Okabe et al., CDNA CLONING OF A NCFI-B NUR77-RELATED TRANSCRIPTION FACTOR FROM AN APOPTOTIC HUMAN T-CELL LINE/, The Journal of immunology, 154(8), 1995, pp. 3871-3879
Citations number
48
Categorie Soggetti
Immunology
Journal title
The Journal of immunology
ISSN journal
00221767 → ACNP
Volume
154
Issue
8
Year of publication
1995
Pages
3871 - 3879
Database
ISI
SICI code
0022-1767(1995)154:8<3871:CCOANN>2.0.ZU;2-M
Abstract
A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore. A new gene, TINUR, was cloned from apopt otic PEER cells. The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell Ag receptor complex. TINUR bel ongs to the NGFI-B/nur77 family of the steroid receptor superfamily an d is an orphan receptor. TINUR binds to the same DNA sequence as NGFI- B/nur77. We also propose that the NGFI-B/nur77 family can be classifie d into two subtypes.