Tc-99m sestamibi has been used to detect primary brain tumors, lung tu
mors, and breast cancers. The authors report a patient who had superio
r vena cava (SVC) syndrome and underwent Tc-99m sestamibi and Tl-201 S
PECT to differentiate the tumor from thrombus in the mediastinum becau
se of an abnormal mass lesion on a contrast enhanced CT scan. An abnor
mal area of increased Tc-99m sestamibi uptake in the supra azygos area
was demonstrated on early and delayed SPECT imaging. The washout of t
umor uptake was slow. The removed tumor was confirmed to be malignant
lymphoma.