AN ASYMMETRIC-SYNTHESIS OF C-2-SYMMETRICAL DIMETHYL 7-DIOXO-CIS-BICYCLO[3.3.0]OCTANE-2,6-DICARBOXYLATE BY LIPASE-CATALYZED DEMETHOXYCARBONYLATION

Authors
NODE M INOUE T ARAKI M NAKAMURA D NISHIDE K
Citation
M. Node et al., AN ASYMMETRIC-SYNTHESIS OF C-2-SYMMETRICAL DIMETHYL 7-DIOXO-CIS-BICYCLO[3.3.0]OCTANE-2,6-DICARBOXYLATE BY LIPASE-CATALYZED DEMETHOXYCARBONYLATION, Tetrahedron letters, 36(13), 1995, pp. 2255-2256
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
13
Year of publication
1995
Pages
2255 - 2256
Database
ISI
SICI code
0040-4039(1995)36:13<2255:AAOCD7>2.0.ZU;2-C
Abstract
Both enantiomers of C-2-symmetric dimethyl 7-dioxo-cis-bicyclo[3.3.0]o ctane-2,6-dicarboxylate (3) were prepared in enantiomerically pure for m by the lipase-catalyzed demethoxycarbonylation, respectively. An exp editious formal total synthesis of (+)carbacyclin using this hybrid pr ocess was done.