STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH BIFUNCTIONAL REAGENTS .4. CHEMOSELECTIVITY DURING OXIDATIVE COUPLING OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH AMINO-ALCOHOLS CONTROLLED BY PROTONATION OF THE AMINO FUNCTION

Authors
SOBKOWSKI M STAWINSKI J KRASZEWSKI A
Citation
M. Sobkowski et al., STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH BIFUNCTIONAL REAGENTS .4. CHEMOSELECTIVITY DURING OXIDATIVE COUPLING OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH AMINO-ALCOHOLS CONTROLLED BY PROTONATION OF THE AMINO FUNCTION, Tetrahedron letters, 36(13), 1995, pp. 2295-2298
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
13
Year of publication
1995
Pages
2295 - 2298
Database
ISI
SICI code
0040-4039(1995)36:13<2295:SORONH>2.0.ZU;2-9
Abstract
The course of oxidative coupling of H-phosphonate diesters with amino alcohols, promoted by iodine, can be controlled by protonation of the amine function of amino alcohols. Based on this phenomenon, a rapid an d efficient method for synthesis of aminoalkyl phosphotriesters or hyd roxyalkyl phosphoramidates was developed.