M. Aktas et al., IN-VIVO QUANTIFICATION OF MUSCLE DAMAGE IN DOGS AFTER INTRAMUSCULAR ADMINISTRATION OF DRUGS, British Veterinary Journal, 151(2), 1995, pp. 189-196
Intramuscular injections of a vitamin B preparation, imidocarb, imidoc
arb+lidocaine, and a preparation of salts of fatty acids produced sign
ificant increases in plasma creatine kinase activity in groups of five
to six dogs. Activities peaked between 3 and 8 h, and were as high as
23 times base values with the fatty acid salts preparation. Quantific
ation of the equivalent muscle damage gave means of 0.04, 0.25, 0.23 a
nd 0.30 g kg(-1) body weight, respectively, for each of the above prep
arations.