MEASURING DRUG EFFECTIVENESS BY DEFAULT - THE CASE OF BENDECTIN

In 1983, Bendectin was voluntarily removed from the market by Merrell Dow Pharmaceuticals Inc. because of the many produce liability suits p ending. Earlier, 10 to 25% of pregnancies were exposed to Bendectin an d over the years the drug was used in as many as 33 million pregnancie s. The scientific evidence available pointed to the safety of Bendecti n. This article considers some of the effects of the withdrawal of the drug. In 1983, hospital admissions for excessive vomiting in pregnanc y per thousand live births rose by 37% over 1980-82 ratios and by 50%, in 1984. In the United States, hospitalization rose by similar amount s. A rough estimate of excess hospital costs over the years 1983-87 is $16 million for Canada and $73 million for the U.S. Such estimates do not take into consideration other costs, such as extra physician visi ts, increased absenteeism from work, and the effect on quality of life of the pregnant woman and her family. No decrease in rates of congeni tal malformations could be shown to offset this increased cost to soci ety.