PHARMACOKINETICS OF HIGH-DOSE INTRAVENOUS CIPROFLOXACIN IN YOUNG AND ELDERLY AND IN MALE AND FEMALE SUBJECTS

Authors
SHAH A LETTIERI J NIX D WILTON J HELLER AH
Citation
A. Shah et al., PHARMACOKINETICS OF HIGH-DOSE INTRAVENOUS CIPROFLOXACIN IN YOUNG AND ELDERLY AND IN MALE AND FEMALE SUBJECTS, Antimicrobial agents and chemotherapy, 39(4), 1995, pp. 1003-1006
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
4
Year of publication
1995
Pages
1003 - 1006
Database
ISI
SICI code
0066-4804(1995)39:4<1003:POHICI>2.0.ZU;2-6
Abstract
The effects of age and gender on the pharmacokinetics of high-dose int ravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than i n the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV s ite.