RIBOSYLATION BY MYCOBACTERIAL STRAINS AS A NEW MECHANISM OF RIFAMPIN INACTIVATION

Authors
DABBS ER YAZAWA K MIKAMI Y MIYAJI M MORISAKI N IWASAKI S FURIHATA K
Citation
Er. Dabbs et al., RIBOSYLATION BY MYCOBACTERIAL STRAINS AS A NEW MECHANISM OF RIFAMPIN INACTIVATION, Antimicrobial agents and chemotherapy, 39(4), 1995, pp. 1007-1009
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
4
Year of publication
1995
Pages
1007 - 1009
Database
ISI
SICI code
0066-4804(1995)39:4<1007:RBMSAA>2.0.ZU;2-U
Abstract
Several fast-growing Mycobacterium strains were found to inactivate ri fampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by thes e organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The st ructures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl- 23- [O-(alpha-D-ribofuranosyl)] rifamycin SV and 23- [O-(alpha-D-ribof uranosyl)] rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivati on.