POPULATION RISK OF BRONCHIAL-ASTHMA IN MO SCOW

Age-specific prevalence and incidence of bronchial asthma (BA) were es timated in a number of districts in Moscow. The average prevalence was measured as the current proportion of BA patients registered in distr ict outpatient clinics of both the center and periphery of Moscow (244 2 patients in total) among the entire population served by to these cl inics. This proportion was found to be 0.5% for both men and women. Be fore 25 years of age, BA appeared to be commoner in males (0.57%, vers us 0.3% in females); after 40 years of age, it was commoner in females (0.89%, versus 0.47% in males). The morbidity of the disease, measure d as the frequency of new cases of BA (diagnosed for the first time in the given patient) had two maximums foreach gender: in females, betwe en birth and nine years of age and at 45 - 54 years (0.39 and 0.45%, r espectively) and in males, between birth and nine years and at 55 - 64 years (0.75 and 0.74%, respectively); and a minimum at 20 - 29 years of age (0.14 and 0.05% for females and males, respectively). The major ity (80%) of adult BA patients were first diagnosed with BA in adultho od. The dynamics of BA incidence appeared to differ in males and femal es. The male incidence changed more drastically with age, while the in cidence in adult females reached a maximum 10 years earlier than in ad ult males. The population risk of being registered for BA (accumulated morbidity) by the age of 15, 40, and 80 was 0.98, 1.35, and 2.97%, re spectively, for males and 0.58, 0.95, and 2.13%, respectively, for fem ales. The risk of BA for children living within the Sadovoe Kol'tso (t he city center) appeared to be almost twofold greater than that for ch ildren living at the city periphery (on average, 1.06%, versus 0.58% b y 15 years of age). The obtained epidemiological data will be used in future in genetic analysis of family data for comparison with the recu rrent risk of the disease in families with different family anamnesis.