LOCALIZATION OF PROTEIN-KINASES BY ANCHORING PROTEINS - A THEME IN SIGNAL-TRANSDUCTION

A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmental ize the kinases to their sites of action. Inhibitors of the interactio ns between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of thes e anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interactio n between the kinases and their anchoring proteins may be useful as th erapeutic agents.