ANTIPROLIFERATIVE EFFECT OF 2-METHOXYESTRADIOL ON CULTURED SMOOTH-MUSCLE CELLS FROM RABBIT AORTA

Authors
NISHIGAKI I SASAGURI Y YAGI K
Citation
I. Nishigaki et al., ANTIPROLIFERATIVE EFFECT OF 2-METHOXYESTRADIOL ON CULTURED SMOOTH-MUSCLE CELLS FROM RABBIT AORTA, Atherosclerosis, 113(2), 1995, pp. 167-170
Citations number
15
Categorie Soggetti
Cardiac & Cardiovascular System","Peripheal Vascular Diseas
Journal title
Atherosclerosis → ACNP
ISSN journal
00219150
Volume
113
Issue
2
Year of publication
1995
Pages
167 - 170
Database
ISI
SICI code
0021-9150(1995)113:2<167:AEO2OC>2.0.ZU;2-7
Abstract
The proliferation of cultured smooth muscle cells from rabbit aorta wa s inhibited markedly by 2-methoxyestradiol, considerably by 2-hydroxye stradiol, and only slightly by 17 beta-estradiol. The effects at doses from 1 to 40 nmol/ml were cytostatic rather than cytocidal, 2-Methoxy estradiol could be useful to suppress excessive proliferation of arter ial smooth muscle cells, and thus to prevent the progression of athero sclerosis.