TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS - AN IMMUNOLOGICAL DISORDER

A 14-year-old boy with tubulointerstitial nephritis and uveitis (TINU syndrome) is described. Nephropathy improved without systemic cortison e treatment, whereas uveitis relapsed and was treated with topical ste roids. Blood cell immunological analysis and serum analysis revealed s igns of cytotoxic T-cell, macrophage and granulocyte activation, which declined as the clinical symptoms improved. This may be interpreted a s an indication of their significance as markers in the pathogenesis o f this syndrome or as part of a microbial-triggered immune response.