IN-VITRO AND IN-VIVO ANTITUMORAL PHENANTHRENES FROM THE AERIAL PARTS OF DENDROBIUM NOBILE

Authors
LEE YH PARK JD BAEK NI KIM SI AHN BZ
Citation
Yh. Lee et al., IN-VITRO AND IN-VIVO ANTITUMORAL PHENANTHRENES FROM THE AERIAL PARTS OF DENDROBIUM NOBILE, Planta medica, 61(2), 1995, pp. 178-180
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
61
Issue
2
Year of publication
1995
Pages
178 - 180
Database
ISI
SICI code
0032-0943(1995)61:2<178:IAIAPF>2.0.ZU;2-M
Abstract
Two phenanthrenes were isolated from the aerial part of Dendrobium nob ile Lindl. and their structures were identified to be 4,7-dihydroxy-2- methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which t he former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV -3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukem ia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of s arcoma 180.