Vco. Njar et al., ANTIFERTILITY ACTIVITY OF QUASSIA-AMARA - QUASSIA INHIBITS THE STEROIDOGENESIS IN RAT LEYDIG-CELLS IN-VITRO, Planta medica, 61(2), 1995, pp. 180-182
The crude methanol extract of the stem wood of Quassia amara L. inhibi
ted both the basal and LH-stimulated testosterone secretion of rat Ley
dig cells in a dose-dependent fashion. Fractionation of the extract by
chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compo
und 1 proved to be the bioactive agent.