CONFORMATIONAL-ANALYSIS AND BIOLOGICAL-ACTIVITY OF LEPTOCARPIN AND LEPTOCARPIN ACETATE

Authors
MARTINEZ R KESTERNICH V GUTIERREZ E DOLZ H MANSILLA H
Citation
R. Martinez et al., CONFORMATIONAL-ANALYSIS AND BIOLOGICAL-ACTIVITY OF LEPTOCARPIN AND LEPTOCARPIN ACETATE, Planta medica, 61(2), 1995, pp. 188-189
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
61
Issue
2
Year of publication
1995
Pages
188 - 189
Database
ISI
SICI code
0032-0943(1995)61:2<188:CABOLA>2.0.ZU;2-9
Abstract
This paper deals with the conformational study in solution of leptocar pin, a germacranolide with the heliangolide structure isolated from Le ptocarpha rivularis D.C. The results obtained agree with the single cr ystal X-ray diffraction studies, Leptocarpin and leptocarpin 50% inhib ition of [S-35]-methionine affecting the (methyl-H-3)thymidine and (5, 6-H-3)uridine incorporation, when assayed in HeLa cells.