Pm. Mauch et al., MANTLE IRRADIATION ALONE FOR SELECTED PATIENTS WITH LAPAROTOMY-STAGEDIA TO IIA HODGKINS-DISEASE - PRELIMINARY-RESULTS OF A PROSPECTIVE TRIAL, Journal of clinical oncology, 13(4), 1995, pp. 947-952
Purpose: To determine the feasibility of omitting prophylactic paraaor
tic irradiation in selected patients with laparotomy-staged (pathologi
cally staged [PS]) IA to IIA Hodgkin's disease. Patients and Methods:
We initiated a prospective single-arm trial in October 1988 to study t
he role of mantle irradiation alone in selected PS IA to IIA patients
with Hodgkin's disease. A total of 37 patients have been entered onto
this trial. Entrance criteria included nodular sclerosis (NS) or lymph
ocyte predominance (LP) histology, absence of B symptoms, disease limi
ted above the carina, and a negative laparotomy. Results of treatment
of 23 patients in the prospective trial, monitored off treatment for g
reater than or equal to 1 year, are presented. Twenty-three additional
PS IA to IIA patients, treated with mantle irradiation alone from 197
0 to 1987, were analyzed as a comparison group. The median follow-up d
urations were 32 and 113 months, respectively, for the two groups. Res
ults: The 4-year actuarial rates of freedom from relapse and overall s
urvival are 83% and 100%, respectively, for the prospective trial. The
10-year actuarial rates of freedom from relapse and overall survival
ore 83% and 89%, respectively, for retrospectively studied patients. T
here have been five recurrences among 46 patients who received mantle
irradiation alone, all with a component of relapse below the diaphragm
. Conclusion: These early results support the use of mantle irradiatio
n alone in selected PS IA to IIA patients with NS or LP histology. Rel
apses, although rare, have occurred predominantly below the diaphragm.
This suggests the need for continued long-term surveillance of abdomi
nal and pelvic nodes in this group of treated patients. J Clin Oncol 1
3:947-952. (C) 1995 by American Society of Clinical Oncology.