INVASIVE CENTRAL-NERVOUS-SYSTEM ASPERGILLOSIS - CURE WITH LIPOSOMAL AMPHOTERICIN-B, ITRACONAZOLE, AND RADICAL SURGERY - CASE-REPORT AND REVIEW OF THE LITERATURE

INVASIVE ASPERGILLOSIS OF the central nervous system is a rare but wel l-described disease. There have been only a few reported survivors, an d mortality exceeds 95% in the immunosuppressed host. We present a 2-y ear-old boy with acute lymphatic leukemia and multiple Aspergillus bra in abscesses who was successfully treated with liposomal amphotericin B, itraconazole, and surgical excision of the abscesses. Liposomal amp hotericin B is a new preparation that safely allows the attainment of significantly higher tissue levels with less toxicity than standard am photericin B. The treatment of patients with invasive central nervous system aspergillosis is reviewed.