PRIMARY CYTOTOXIC RESPONSE OF BOVINE PERIPHERAL-BLOOD LEUKOCYTES TO PARAINFLUENZA TYPE-3 VIRUS-INFECTION

Authors
BAMFORD AI ADAIR BM FOSTER JC
Citation
Ai. Bamford et al., PRIMARY CYTOTOXIC RESPONSE OF BOVINE PERIPHERAL-BLOOD LEUKOCYTES TO PARAINFLUENZA TYPE-3 VIRUS-INFECTION, Veterinary immunology and immunopathology, 45(1-2), 1995, pp. 85-95
Citations number
16
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
45
Issue
1-2
Year of publication
1995
Pages
85 - 95
Database
ISI
SICI code
0165-2427(1995)45:1-2<85:PCROBP>2.0.ZU;2-Q
Abstract
Peripheral blood mononuclear cells were isolated from calves following Parainfluenza Type-3 (PI-3) virus infection and incubated with autolo gous and non-autologous PI-3 virus-infected muscle cells in a 4 h chro mium release assay. Peaks of cytotoxicity, which ranged from 12% to 53 % were observed between Days 6 and 9 post infection, with an effector to target cell ratio of 100:1. Killing of PI-3 virus-infected or uninf ected mismatched muscle cells was never more than 5%.