Transthoracic percutaneous needle biopsy has become popular for evalua
tion of pulmonary nodules. However, it is a procedure with morbidity a
nd mortality that is not negligible. In this article, we report massiv
e air embolus complicating needle biopsy in a patient with amyloidosis
. A negative biopsy does not exclude malignancy, and if surgical excis
ion will be performed regardless of the result, preoperative assessmen
t using this technique may not be necessary.