RENAL-FAILURE DURING ACUTE TOXICITY PRODUCED BY TULLIDORA INGESTION (KARWINSKIA-HUMBOLDTIANA)

Authors
JARAMILLOJUAREZ F ORTIZ GG RODRIGUEZVAZQUEZ ML FALCONFRANCO MA FERIAVELASCO A
Citation
F. Jaramillojuarez et al., RENAL-FAILURE DURING ACUTE TOXICITY PRODUCED BY TULLIDORA INGESTION (KARWINSKIA-HUMBOLDTIANA), General pharmacology, 26(3), 1995, pp. 649-653
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
3
Year of publication
1995
Pages
649 - 653
Database
ISI
SICI code
0306-3623(1995)26:3<649:RDATPB>2.0.ZU;2-W
Abstract
1. Acute effects of Karwinskia humboldtiana (Kh) were studied in some renal functions and structural patterns of renal tissue. 2. Haemodinam ic changes were observed with decrements of the glomerular filtration rate, renal plasma how and filtration fraction during acute intoxicati on.3. A marked increment in the fractional excretion of sodium was obs erved in the rats treated with tullidora fruits (Kh). 4. Cloudy swelli ng and hydropic degeneration was seen 72 hr after intoxication, mainly in the proximal convoluted tubules.