THE EFFECT OF TOPICAL CCNU(1-(2-CHLOROETHYL)-3 CYCLOHEXYL-1 NITROSUREA) TREATMENT ON LIPID-PEROXIDATION OF GLIAL TUMORS TRANSPLANTED ON RAT-BRAIN

1. The effect of topical CCNU treatment on lipid peroxidation of glial tumors transplanted on rat brain has been investigated in 22 rats. 2. Four groups have been selected as normal brain tissue, normal brain t issue + CCNU, tumour tissue, tumour tissues CCNU. In these groups malo ndialdehyde (MDA) levels have been measured as a marker of lipid perox idation. 3. Lipid peroxidation was high in tumour tissue in respect to controls (P < 0.05). In normal tissues topical CCNU treatment caused increase in lipid peroxidation (P < 0.05). In tumor tissues, topical C CNU decreased lipid peroxidation (P < 0.05). It is concluded that furt her studies have to be performed in order to determine whether increas es in lipid peroxidation on CCNU treated normal brain tissues is a res ult of the inhibitory effect on cellular defence systems or promotion of free radical production.