NUCLEOTIDE-SEQUENCE OF A ASPERGILLUS-PARASITICUS GENE STRONGLY REPRESSED BY THIAMINE

Authors
CARY JW BHATNAGAR D
Citation
Jw. Cary et D. Bhatnagar, NUCLEOTIDE-SEQUENCE OF A ASPERGILLUS-PARASITICUS GENE STRONGLY REPRESSED BY THIAMINE, Biochimica et biophysica acta, N. Gene structure and expression, 1261(2), 1995, pp. 319-320
Citations number
7
Categorie Soggetti
Biology,Biophysics,"Biothechnology & Applied Migrobiology
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1261
Issue
2
Year of publication
1995
Pages
319 - 320
Database
ISI
SICI code
0167-4781(1995)1261:2<319:NOAAGS>2.0.ZU;2-X
Abstract
A cDNA clone demonstrating a high degree of homology to the thiamine r epressed nmt1 gene of Schizosaccharomyces pombe was isolated from the aflatoxigenic fungus; Aspergillus parasiticus. The deduced polypeptide of a cDNA clone from A. parasiticus had an amino acid sequence identi ty of 60% with that of the nmtI gene of S. pombe. Transcription of the nmt1 gene homolog in the fungus was strongly inhibited by concentrati ons of thiamine of 2.0 mu M or higher.