L. Koblinger et W. Hofmann, AEROSOL INHALATION IN THE RAT LUNG .2. THEORETICAL PREDICTIONS OF PARTICLE DEPOSITION PATTERNS, Journal of aerosol medicine, 8(1), 1995, pp. 21-32
Theoretical predictions of total, regional and local deposition fracti
ons of inhaled particles are based on the complete stochastic model of
the rat lung presented in Part I (Koblinger et al., 1995). Deposition
patterns of inhaled particles ranging from 0.01 to 10 mu m diameter a
re computed for two stochastic rat lung models differing only in their
respective tracheobronchial morphometries. Deposition fractions based
on the two stochastic morphometric models are compared to correspondi
ng results utilizing the deterministic lung model of Yeh et al. (1979)
as well as to the available experimental evidence. In contrast to the
simulations with the presently used deterministic model of the rat lu
ng and our previous stochastic model of the human lung, the differenti
al distributions of deposited matter throughout the rat airway system
are expressed as functions of the airway diameter, which permits a mor
e realistic description of the rather monopodial structure of the rat
lung.