An. Ruiz et al., ANTICONVULSANT ACTIVITY OF CASIMIROA-EDULIS IN COMPARISON TO PHENYTOIN AND PHENOBARBITAL, Journal of ethnopharmacology, 45(3), 1995, pp. 199-206
An aqueous extract of Casimiroa edulis leaves was tested in adult male
Wistar rats for anticonvulsant activity utilizing two models of exper
imental epilepsy: maximal electroshock seizure (MES) and subcutaneousl
y injected metrazole (METsc). Single dose of 100 mg/kg C. edulis vacuu
m dried aqueous extracts (VDA) orally administered to experimental ani
mals elicited 50% and 70% abolition of MES and METsc-induced seizures,
respectively. Two firmly established antiepileptic drugs in human the
rapy, phenytoin (PHT) and phenobarbital (PB), abolished 90% of MES-ind
uced seizures, whereas an 80% and 100% absence of clonic seizures was
attained in METsc test, correspondingly. The seizure abolition observe
d in C. edulis VDA treated rats was comparable with the anticonvulsive
pattern exhibited by PHT and PB. These results suggest that potencial
ly antiepileptic compounds are present in C. edulis extracts that dese
rve the study of their identity and mechanism of action.