Z. Storchova et al., ACCUMULATION OF ADE(-CEREVISIAE ALLELIC IN RAD6 DURING ADENINE STARVATION() REVERSIONS IN ISOAUXOTROPHIC STRAINS OF SACCHAROMYCES), Folia microbiologica, 42(1), 1997, pp. 47-51
A comparative method based on an analysis of accumulation of starvatio
n-induced Ade(+) reversions and cell death during adenine starvation w
as developed and exploited for estimating the role of RAD6 in the star
vation-induced reversions. It was shown that inactivation of RAD6 func
tion in Saccharomyces cerevisiae markedly enhances the accumulation of
Ade(+) reversions, and therefore it is likely that this gene is takin
g part in maintaining the low level of starvation-induced mutations in
yeast cells.