RESEARCH ON ANTIFUNGAL AND ANTIMYCOBACTERIAL AGENTS - SYNTHESIS AND ACTIVITY OF 4-ALKYLTHIOPYRIDINE-2-CARBOTHIOAMIDES

A series of 4-alkylthiopyridine-2-carbothioamides have been prepared a nd evaluated in vitro for antimicrobial activity. Chemical structures have been demonstrated by IR and H-1 NMR data and by elemental analysi s. The antimycobacterial activity of these compounds against Mycobacte rium tuberculosis, Mycobacterium kansasii, Mycobacterium avium, and My cobacterium fortuitum, and the antifungal activity against Candida alb icans, Candida tropicalis, Candida krusei, Candida glabrata, Trichospo ron beigelii, Trichophyton mentagrophytes, Aspergillus fumigatus, and Absidia corymbifera were determined by the MIC values. Compounds 3 exh ibit good antimycobacterial activity compared to isoniazide. A moderat e antifungal activity was observed against T. mentagrophytes. Activity is influenced by hydrophobicity of the alkyl group.