Ha. Weiler et al., DEXAMETHASONE TREATMENT IMPAIRS CALCIUM REGULATION AND REDUCES BONE MINERALIZATION IN INFANT PIGS, The American journal of clinical nutrition, 61(4), 1995, pp. 805-811
Calcium and vitamin D metabolism, bone mineralization, and growth were
studied in piglets randomly assigned to 15 d of dexamethasone (0.5 mg
. kg(-1). d(-1), orally) or placebo. Growth velocity was significantl
y reduced by dexamethasone treatment (P < 0.001). Pigs in the dexameth
asone group demonstrated lower Ca-45 absorption by in situ intestinal
perfusion (P < 0.01). Plasma 25-hydroxycholecalciferol (calcidiol) and
1,25-dihydroxycholecalciferol (calcitriol) were lower (P < 0.05) and
the urinary ratio of calcium to creatinine was higher (P < 0.05) after
15 d of dexamethasone compared with placebo. Differences between pre-
and postosteocalcin (P < 0.01) and pyridinoline (P < 0.01) were highe
r and whole-body, lumbar, and femur bone mineral density were lower (P
< 0.05) in dexamethasone-treated piglets. Dexamethasone-induced reduc
tions in bone mineral mass likely result from reduced vitamin D status
, reduced intestinal calcium absorption, elevated urinary calcium loss
and direct effects of the steroid on bone. When dexamethasone is used
in premature infants to improve lung function, negative effects on gr
owth and bone metabolism could occur.