W. Roeffen et al., TRANSMISSION-BLOCKING IMMUNITY AS OBSERVED IN A FEEDER SYSTEM AND SEROLOGICAL REACTIVITY TO PFS-48 45 AND PFS230 IN-FIELD SERA/, Memorias do Instituto Oswaldo Cruz, 89, 1994, pp. 13-15
Monoclonal antibodies (mAbs) and human sera from gametocyte carriers w
ere applied in the bio-assay to test for their transmission-blocking c
apacity. Competition ELISA's have been developed for the detection of
natural transmission blocking antibodies. Approximately 55% of the ser
a blocking in the bio-assay gave positive results in these competition
ELISA's.