SENSITIVITY TO 35-PERCENT CO2 IN HEALTHY FIRST-DEGREE RELATIVES OF PATIENTS WITH PANIC DISORDER

Citation
G. Perna et al., SENSITIVITY TO 35-PERCENT CO2 IN HEALTHY FIRST-DEGREE RELATIVES OF PATIENTS WITH PANIC DISORDER, The American journal of psychiatry, 152(4), 1995, pp. 623-625
Citations number
11
Categorie Soggetti
Psychiatry,Psychiatry
ISSN journal
0002953X
Volume
152
Issue
4
Year of publication
1995
Pages
623 - 625
Database
ISI
SICI code
0002-953X(1995)152:4<623:ST3CIH>2.0.ZU;2-5
Abstract
Objective: The authors tested the hypothesis that hyperreactivity to C O2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 a nd 65% O-2 was administered to each of 84 patients with panic disorder , 23 healthy first-degree relatives of probands with panic disorder, a nd 44 healthy subjects with no family history of panic disorder. Resul ts: The first-degree relatives of the probands with panic disorder rea cted significantly more than the healthy subjects and significantly le ss than the probands. Conclusions: These findings suggest an associati on between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.