Until the late 80s, penicillin G or amoxicillin remained the standard
antimicrobial therapy used for community-acquired meningitis in adults
. Guidelines on which drug to use, both empirically and after bacteria
l identification; have been changed in the light of altered susceptibi
lity patterns. Although N. meningitidis strains - relatively resistant
to penicillin G-have been recently isolated, MICs remain below 1 mg/l
and allow the use of amoxicillin (150 mg/kg/d).