STEREOSELECTIVE BINDING OF BENZODIAZEPINES AND RELATED-COMPOUNDS ON CALMODULIN-SEPHAROSE

Authors
FITOS I VISY J KARDOS J SIMONYI M
Citation
I. Fitos et al., STEREOSELECTIVE BINDING OF BENZODIAZEPINES AND RELATED-COMPOUNDS ON CALMODULIN-SEPHAROSE, Chirality, 7(2), 1995, pp. 69-73
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
7
Issue
2
Year of publication
1995
Pages
69 - 73
Database
ISI
SICI code
0899-0042(1995)7:2<69:SBOBAR>2.0.ZU;2-5
Abstract
A method has been presented to evaluate the Ca2+-dependent binding aff inity of ligands to calmodulin (CaM) from their chromatographic retent ions obtained on a CaM-Sepharose column. Enantiomers of benzodiazepine s and related compounds could be separated. Among chiral calcium antag onists, verapamil showed stereoselectivity of binding. (C) 1995 Wiley- Liss, Inc.