EVALUATION OF REGIONAL CEREBRAL BLOOD-FLOW IN MASSIVE INTRACEREBRAL CALCIFICATIONS

Fahr's disease is histopathologically characterized by massive bilater al calcifications of the cerebral basal ganglia, the dentate nuclei of the cerebellum and both the cerebral and cerebellar cortices. We repo rt a case of Fahr's disease in which a Tc-99m-hexamethyl-propylenamine oxime (Tc-99m-HMPAO) brain SPECT study was used to evaluate regional cerebral blood flow to the calcified regions. There was markedly decre ased perfusion to the basal ganglia bilaterally as well as decreased p erfusion to the cerebral cortices that correlated well with the patien t's clinical condition.