This report reviews the evidence for and against clinical use of ambul
atory blood pressure monitoring (ABPM) on a large scale. Such monitori
ng is supported by a number of data, among which is that the end-organ
damage associated with hypertension correlates more with 24-h average
blood pressure than with clinic blood pressure, the correlation becom
ing even closer with addition of blood pressure variability values. Ho
wever, the evidence thus far collected is largely cross-sectional, Fur
thermore, ABPM devices have limited accuracy and the procedure has a h
igh cost. Therefore, while prospective studies on the prognostic value
of ambulatory blood pressure are awaited, use of this approach should
be restricted to a limited number of clinical circumstances (e.g., id
entification of white-coat hypertension) and used only in specialized
centers.