HIV-1 VARIANTS IN SOUTH AND SOUTH-EAST ASIA

HIV spread in South and South-East Asia is most alarming, and genetic variability of HIV-1 is an important consideration in vaccine developm ent. In this study, we examined the third variable (V3) region of env gene of HIV-1 variants prevalent in Thailand, Malaysia, India, and the Philippines. By phylogenetic tree analyses, an HIV-1 variant from an injecting drug user (IDU) in Thailand belonged to subtype B, and HIV-1 variants from 2 IDUs in Malaysia were classified into 2 subtypes, B a nd E. One HIV-1 variant from a male homosexual in the Philippines belo nged to subtype B. Out of 8 HIV-1 variants from sexually transmitted d isease patients in India, 7 belonged to subtype C, and one to subtype A. Although the total number of individuals examined in this study was limited, 4 HIV-1 subtypes were found in South and South-East Asia and large international movements of HIV-1-infected individuals in this r egion could induce global dissemination of these HIV-1 variants.