AQUEOUS PENETRATION OF ORALLY-ADMINISTERED CIPROFLOXACIN IN HUMANS

The aqueous penetration of orally administered Ciprofloxacin (CPX) was studied in twenty-two human volunteers undergoing cataract surgery. C PX in a dose of 250 mg, was given p.o. at 12 hourly intervals in 3 gro ups such that a maximum dose of 0.5 grams was delivered in one group, 1.0 grams in another and 1.5 grams in the last group. A fourth group c onsisted of 6 individuals who were controls and received lactose table ts. Twelve hours after the last dosing aqueous samples were collected and assayed by the Grove-Randall technique. The aqueous penetration of Ciprofloxacin achieved was 1.51 +/- 0.15 mgL(-1) in group II and 2.49 +/- 0.52 mgL(-1) in group III, In group I, the aqueous concentration was experimentally indeterminate and the control samples in group IV d id not show any antibacterial activity. Divided oral doses of 1.5 gram s of CPX were found to produce an aqueous titre up to 2.5 times the MI C of Ps. aeruginosa.