INTRAMOLECULARLY ALKYLATED COSTA COMPLEXES - NEW MODELS FOR COENZYME B-12 WITH A COBALT-TO-LIGAND CARBON BRIDGE

Authors
VANARKEL B VANDERBAAN JL BALT S BICKELHAUPT F DEBOLSTER MWG KLUMPP GW
Citation
B. Vanarkel et al., INTRAMOLECULARLY ALKYLATED COSTA COMPLEXES - NEW MODELS FOR COENZYME B-12 WITH A COBALT-TO-LIGAND CARBON BRIDGE, Tetrahedron, 51(14), 1995, pp. 4161-4172
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
14
Year of publication
1995
Pages
4161 - 4172
Database
ISI
SICI code
0040-4020(1995)51:14<4161:IACC-N>2.0.ZU;2-N
Abstract
The synthesis of Costa-type B-12 models 1 with a carbon bridge between the equatorial ligand and cobalt has been accomplished by condensatio n of butanedione monoxime and 2-(omega-functionalized)alkyl-1,3-diamin opropanes 8 followed by complexation with Co(II), introduction of a le aving group and intramolecular alkylation via Co(I) intermediates. The solution structure of intramolecularly alkylated Costa complexes with a bridge of two (1a) or of three (1b) methylene groups was investigat ed by NMR spectroscopy and compared with that of propyl(iodo) Costa co mplex 13.