COMPARISON OF HALOTHANE, ENFLURANE AND ISOFLURANE KIDNEY EFFECTS THROUGH ALANINE AMINOPEPTIDASE URINE CREATININE VALUES

The kidney effects of halothane, enflurane and isoflurane were evaluat ed by using the ratio of urinary excretion of alanine aminopeptidase ( AAP) to urine creatinine. Thirty patients in ASA class 1 or 2 were stu died, None had renal disease nor received nephrotoxic drugs. Groups 1, 2 and 3 received halothane, enflurane and isoflurane respectively, Cr eatinine and AAP activities in urine spot tests, serum creatinine and BUN levels were determined preoperatively and on the first and second postoperative days. Urine AAP activity and AAP/urine creatinine values increased significantly on the first and second postoperative days co mpared with the preoperative values in all groups (P < 0.05). The pres ent study did not reveal any significant difference in the kidney effe cts of halothane, enflurane and isoflurane through AAP/creatinine in s pot urine values.