There is a striking similarity between the situations;avoided by peopl
e with agoraphobia and the environments which provoke disorientation i
n people with organic balance disorders. This study investigated the p
ossibility that agoraphobia might be linked to balance system dysfunct
ion by comparing the results of balance system tests in 36 people with
symptoms of panic and agoraphobia and 20 normal controls. A tradition
al battery of audiovestibular tests was supplemented with moving platf
orm posturography, which assesses the postural instability induced by
disorienting perceptual conditions. Subjects also completed questionna
ire measures of somatic symptoms of dizziness and anxiety, agoraphobic
cognitions, avoidance behaviour and state anxiety. Over 60% of the Ss
with symptoms of panic and agoraphobia were destabilised by the disor
ienting perceptual conditions, compared with just 10% of the normal co
ntrols. Postural instability was strongly related to reported agorapho
bic avoidance (r = 0.63, P < 0.01), even after controlling for symptom
s, anxiety and agoraphobic cognitions. In our discussion we consider a
lternative interpretations of these findings, future directions for re
search, and implications for therapy.