CEPHALOSTATIN CHEMISTRY .5. CHROMIUM[II]-MEDIATED REDUCTIVE CLEAVAGE OF A TERTIARY HALIDE BEARING 3 BETA-ALKOXY GROUPS - SYNTHESIS OF THE NORTH HEXACYCLIC STEROID UNIT OF THE CEPHALOSTATIN FAMILY

Authors
KIM SK SUTTON SC FUCHS PL
Citation
Sk. Kim et al., CEPHALOSTATIN CHEMISTRY .5. CHROMIUM[II]-MEDIATED REDUCTIVE CLEAVAGE OF A TERTIARY HALIDE BEARING 3 BETA-ALKOXY GROUPS - SYNTHESIS OF THE NORTH HEXACYCLIC STEROID UNIT OF THE CEPHALOSTATIN FAMILY, Tetrahedron letters, 36(14), 1995, pp. 2427-2430
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
14
Year of publication
1995
Pages
2427 - 2430
Database
ISI
SICI code
0040-4039(1995)36:14<2427:CC.CRC>2.0.ZU;2-2
Abstract
Transformation of aldehyde 4 to 17nat, a hexacyclic steroid bearing th e requisite functionality and spiroketal stereochemistry of the North portion of the cephalostatin family is described. The key reaction inv olves CrCl2 mediated reductive cleavage of a tertiary bromide which is beta to three alkoxy groups.